MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

Results: HTML CSV LaTeX

Showing element 451 to 500 of 948 in total

Class  : biological process

Ratio	Gene Ontology	Regulation	description
1.49923	blood vessel development	down	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]
	cell-cell adhesion
	platelet-derived growth factor receptor signaling pathway
	regulation of small GTPase mediated signal transduction
	signal transduction
	small GTPase mediated signal transduction
	transmembrane receptor protein tyrosine kinase signaling pathway
1.50206	ceramide biosynthetic process	up	LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]
	lipid biosynthetic process
	regulation of transcription, DNA-dependent
1.50284	intracellular protein transport	down	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]
	protein complex assembly
	transport
	vesicle-mediated transport
1.50715	ubiquitin cycle		F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]
1.51342	chemotaxis		Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). [Uniprot/SWISSPROT;Acc:O15263]
	defense response
	defense response to bacterium
	G-protein coupled receptor protein signaling pathway
	immune response
1.5415	chloride transport		Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]
	intracellular signaling cascade
	signal transduction
1.54317	determination of left/right symmetry	up	Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]
	protein amino acid glycosylation
1.54676	cell adhesion	down	WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]
1.55809	GPI anchor biosynthetic process		Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]
	protein modification process
1.55844	intracellular signaling cascade	up	TP53-target gene 5 protein (TP53-inducible gene 5 protein). [Uniprot/SWISSPROT;Acc:Q9Y2B4]
	negative regulation of cell growth
1.57088	caudate nucleus development		Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]
	putamen development
	regulation of transcription, DNA-dependent
	transcription
1.58045	peroxisome organization and biogenesis	down	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]
1.59177	actomyosin structure organization and biogenesis	up	Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]
	muscle development
1.59188	regulation of transcription, DNA-dependent		Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]
	transcription
1.59763	protein modification process	down	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]
	ubiquitin cycle
1.59819	detection of stimulus during sensory perception	up	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]
	protein amino acid dephosphorylation
	response to stimulus
	visual perception
1.60668	calcium ion homeostasis		Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]
	calcium ion transport
	ion transport
	osmosensory signaling pathway
	regulation of cell volume

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.