MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 450 to 499 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	3.54928	cellular component	membrane
		molecular function	glycerophosphodiester phosphodiesterase activity
			hydrolase activity
Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	3.11758	biological process	growth
		cellular component	extracellular region
			extracellular space
		molecular function	cytokine activity
			growth factor activity
Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]	2.44552	biological process	G-protein coupled receptor protein signaling pathway
			protein amino acid ADP-ribosylation
			signal transduction
		cellular component	heterotrimeric G-protein complex
			plasma membrane
		molecular function	GTP binding
			GTPase activity
			guanyl nucleotide binding
			nucleotide binding
			signal transducer activity
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	3.54799	biological process	G-protein coupled receptor protein signaling pathway
			signal transduction
		molecular function	calcium channel regulator activity
			GTPase activity
			protein binding
			signal transducer activity
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	1.1611	biological process	electron transport
			signal transduction
		cellular component	extracellular region
		molecular function	electron carrier activity
			enzyme activator activity
			guanylate cyclase activator activity
			hormone activity
Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	3.62109	cellular component	nucleus
Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	1.27461	biological process	anatomical structure morphogenesis
			G-protein coupled receptor protein signaling pathway
			multicellular organismal development
			regulation of transcription, DNA-dependent
			thyroid gland development
		cellular component	integral to membrane
			nucleus
		molecular function	DNA binding
			galanin receptor activity
			sequence-specific DNA binding
			transcription factor activity
Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	3.48313	biological process	regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	sequence-specific DNA binding
			transcription factor activity
Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	1.23845	biological process	cell proliferation
			cholesterol metabolic process
			lipid metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.