MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 443 to 492 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.22502	up	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	cellular component	lamellar body
				membrane fraction
				plasma membrane
			molecular function	ATP binding
				ATPase activity
				ATPase activity, coupled to transmembrane movement of substances
				nucleoside-triphosphatase activity
				nucleotide binding
				transporter activity
1.22528		protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]	biological process	dephosphorylation
				protein amino acid dephosphorylation
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein tyrosine phosphatase activity
				protein tyrosine/serine/threonine phosphatase activity
1.22576		Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	biological process	negative regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	DNA binding
				metal ion binding
				methyl-CpG binding
				protein binding
				transcription corepressor activity
				transcription factor activity
				zinc ion binding
1.22694		Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]	biological process	type I hypersensitivity
1.23668	down	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]		biological_process
			cellular component	myosin complex
				unconventional myosin complex
			molecular function	actin binding
				ATP binding
				calmodulin binding
				motor activity
				nucleoside-triphosphatase activity
				nucleotide binding
1.23783		Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]	biological process	regulation of GTPase activity
				signal transduction
			cellular component	cytoplasm
				intracellular
			molecular function	GTPase activator activity
				metal ion binding
				phosphatidylinositol-3,4,5-triphosphate binding
				zinc ion binding
1.23845		Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	biological process	cell proliferation
				cholesterol metabolic process
				lipid metabolic process
				metabolic process
				response to sterol depletion

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.