MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

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Showing element 401 to 450 of 948 in total

Class  : biological process

Ratio	Regulation	Gene Ontology	description
1.45624	up	hemostasis	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
		multicellular organismal development
		regulation of transcription
		regulation of transcription from RNA polymerase II promoter
		regulation of transcription, DNA-dependent
1.45635		cell cycle	Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]
		cell division
		mitosis
		mitotic G2 checkpoint
		positive regulation of transcription
		regulation of cyclin-dependent protein kinase activity
		regulation of progression through cell cycle
1.4628		cell adhesion	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]
		homophilic cell adhesion
1.48363	down	cell cycle	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]
		cell division
		mitosis
		protein amino acid phosphorylation
		regulation of progression through cell cycle
1.48389		ATP synthesis coupled proton transport	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]
		intracellular protein transport across a membrane
		mRNA transport
		protein transport
1.49264	up	electron transport	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]
1.49271	down	cell cycle	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]
		DNA repair
		ubiquitin cycle
1.49444	up	protein modification process	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]
		ubiquitin cycle
1.49558	down	BMP signaling pathway	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]
		bone mineralization
		cardiac cell differentiation
		cartilage development
		cell fate commitment
		cell growth
		cell-cell signaling
		embryonic development
		epithelial to mesenchymal transition
		growth
		inflammatory response
		negative regulation of cell proliferation
		negative regulation of progression through cell cycle
		odontogenesis (sensu Vertebrata)
		organ morphogenesis
		osteoblast differentiation
		positive regulation of astrocyte differentiation
		positive regulation of ossification
		positive regulation of osteoblast differentiation
		regulation of transcription
		ureteric bud branching

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.