MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 400 to 449 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	1.693	down	molecular function	iron-sulfur cluster binding
CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]	1.32602		biological process	protein metabolic process
			molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]	1.23783		biological process	regulation of GTPase activity
				signal transduction
			cellular component	cytoplasm
				intracellular
			molecular function	GTPase activator activity
				metal ion binding
				phosphatidylinositol-3,4,5-triphosphate binding
				zinc ion binding
Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	1.78708	up	cellular component	chromosome
				chromosome, pericentric region
				nucleus
Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	2.7017		biological process	chromosome organization and biogenesis (sensu Eukaryota)
				G-protein signaling, adenylate cyclase inhibiting pathway
				nucleosome assembly
				synaptic transmission
			cellular component	chromosome
				chromosome, pericentric region
				extracellular region
				nucleosome
				nucleus
				soluble fraction
			molecular function	DNA binding
				G-protein-coupled receptor binding
				hormone activity
				neuropeptide hormone activity
Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]	1.31661		biological process	anion transport
				cytochrome complex assembly
				excretion
				heme transport
				sulfate transport
				transport
			cellular component	apical plasma membrane
				brush border membrane
				integral to membrane
				membrane
				membrane fraction
			molecular function	anion exchanger activity
				antiporter activity
				chloride ion binding
				heme transporter activity
				sulfate porter activity
				transcription cofactor activity
				transcription factor activity
				transporter activity
Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	1.78439		biological process	chromatin assembly or disassembly
				chromatin modification
				chromosome organization and biogenesis (sensu Eukaryota)

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.