MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene	Gene Ontology	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 390 to 439 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.21657	up	biological process	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	regulation of exocytosis
				small GTPase mediated signal transduction
				synaptic vesicle targeting
		cellular component		plasma membrane
				synaptic vesicle
				synaptosome
		molecular function		GTP binding
				GTPase activity
				nucleotide binding
				protein binding
				structural molecule activity
				syntaxin binding
1.21698		biological process	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]	electron transport
				metabolic process
		molecular function		oxidoreductase activity
				protein binding
1.21705		biological process	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]	cellular protein metabolic process
				protein amino acid phosphorylation
				protein folding
				regulation of progression through cell cycle
		cellular component		chaperonin-containing T-complex
				cytoplasm
				cytosol
		molecular function		ATP binding
				nucleotide binding
				protein binding
				protein kinase activity
				unfolded protein binding
1.21871	down	biological process	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	apoptotic program
				induction of apoptosis
				regulation of apoptosis
		cellular component		integral to membrane
				membrane
				mitochondrial envelope
		molecular function		protein binding
1.22047	up	biological process	HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	mitosis
		cellular component		nucleus
1.22178		biological process	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	protein amino acid phosphorylation
		cellular component		cytoplasm
				cytosol
				nucleus
		molecular function		ATP binding
				heme binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
				transition metal ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.