MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

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Showing element 390 to 439 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	1.683	molecular function	GDP-dissociation stimulator activity
			hydrolase activity
			ribonuclease activity
			RNA binding
F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]	2.33107	biological process	ubiquitin cycle
		cellular component	SCF ubiquitin ligase complex
		molecular function	protein binding
F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	1.50715	biological process	ubiquitin cycle
		molecular function	protein binding
Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	1.82311	biological process	cell proliferation
			cell-cell signaling
			fibroblast growth factor receptor signaling pathway
			glial cell differentiation
			nervous system development
			regulation of progression through cell cycle
		cellular component	extracellular space
		molecular function	growth factor activity
Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	1.30142	biological process	cell growth
			fibroblast growth factor receptor signaling pathway
			forebrain development
			hair cell differentiation
			inner ear development
			JAK-STAT cascade
			MAPKKK cascade
			morphogenesis of an epithelium
			negative regulation of epithelial cell proliferation
			positive regulation of apoptosis
			positive regulation of cell differentiation
			positive regulation of peptidyl-tyrosine phosphorylation
			positive regulation of protein ubiquitination
			protein amino acid phosphorylation
			sensory perception of sound
			skeletal development
		cellular component	integral to membrane
			integral to plasma membrane
			internal side of plasma membrane
			lysosome
			membrane
			perinuclear region of cytoplasm
		molecular function	ATP binding
			fibroblast growth factor receptor activity
			identical protein binding
			interleukin-1 receptor activity
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			receptor activity
			transferase activity
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	1.33817	biological process	autophagic vacuole formation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.