MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Class	Gene Ontology	Gene	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 351 to 400 of 2667 in total

description	Regulation	Ratio	Class	Gene Ontology
Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438]	down	1.30802	molecular function	ATPase activity, coupled to transmembrane movement of substances
				nucleoside-triphosphatase activity
				nucleotide binding
				organic anion transporter activity
				transporter activity
Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]		1.43351	biological process	proteolysis
				vacuolar protein catabolic process
			molecular function	carboxypeptidase A activity
				carboxypeptidase activity
				metal ion binding
				metallopeptidase activity
				zinc ion binding
Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	up	2.70687	biological process	homoiothermy
				response to freezing
				translation
			cellular component	intracellular
				ribosome
			molecular function	calcium ion binding
				ice binding
				structural constituent of ribosome
CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]	down	1.30082	biological process	regulation of global transcription from RNA polymerase II promoter
				regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	cytoplasm
				nucleus
			molecular function	RNA polymerase II transcription mediator activity
				transcription regulator activity
CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]		2.88128	cellular component	integral to membrane
				membrane
			molecular function	sugar binding
CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]	up	1.98149	biological process	anti-apoptosis
				B cell differentiation
				B cell proliferation
				immune response
				inflammatory response
				isotype switching
				leukocyte adhesion
				platelet activation
				regulation of immunoglobulin secretion
			cellular component	extracellular space
				integral to membrane
				integral to plasma membrane
				membrane
				soluble fraction
			molecular function	CD40 receptor binding
				cytokine activity
				tumor necrosis factor receptor binding
CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	down	1.693	biological process	metabolic process
			molecular function	catalytic activity
				iron-sulfur cluster binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.