MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 340 to 389 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	6.56408	molecular function	protein binding
Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	1.41851	biological process	MAPKKK cascade
			nervous system development
			transmembrane receptor protein tyrosine kinase signaling pathway
		molecular function	insulin receptor binding
			transmembrane receptor protein tyrosine kinase signaling protein activity
E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	1.30869	biological process	cell cycle
			cell division
			mitosis
			mitotic cell cycle
			mitotic checkpoint
			protein polyubiquitination
			ubiquitin cycle
			ubiquitin-dependent protein catabolic process
		cellular component	cellular_component
			nucleus
		molecular function	ligase activity
			metal ion binding
			protein binding
			ubiquitin-protein ligase activity
			zinc ion binding
Echinoderm microtubule-associated protein-like 5 (EMAP-5). [Uniprot/SWISSPROT;Acc:Q05BV3]	2.11557	cellular component	cytoplasm
			microtubule
Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	4.50619	biological process	apoptosis
			phagocytosis
		cellular component	cytoplasm
			cytoskeleton
			membrane
Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	4.49282	biological process	chromatin modification
			negative regulation of gene expression, epigenetic
			negative regulation of transcription from RNA polymerase II promoter
			positive regulation of transcription from RNA polymerase II promoter
			regulation of cell growth
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nuclear membrane
			nucleoplasm
			nucleus
		molecular function	transcriptional activator activity
			transcriptional repressor activity
Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	2.51088	biological process	lipid metabolic process
			transport
		molecular function	binding
			structural constituent of cell wall
			transporter activity
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	1.683	biological process	rRNA processing
		cellular component	cytoplasm
			exosome (RNase complex)
			nucleus
		molecular function	exonuclease activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.