MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 301 to 350 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	1.61347	down	molecular function	calcium ion binding
				protein binding
Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	2.87038	up	biological process	muscle development
				proteolysis
				response to calcium ion
				response to drug
				sarcomere organization
			cellular component	cytoplasm
				intracellular
				nucleus
			molecular function	calcium ion binding
				calpain activity
				cysteine-type endopeptidase activity
				peptidase activity
				protein binding
				signal transducer activity
Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	3.27919	down	biological process	apoptosis
				behavior
				ion transport
				negative regulation of transcription from RNA polymerase II promoter
				potassium ion transport
				regulation of neuron apoptosis
				regulation of transcription from RNA polymerase II promoter
				response to pain
				sensory perception of pain
				signal transduction
				transcription
			cellular component	cytoplasm
				cytosol
				endoplasmic reticulum
				Golgi apparatus
				membrane
				nucleus
			molecular function	calcium ion binding
				calcium-dependent protein binding
				DNA binding
				ion channel activity
				potassium channel activity
				potassium ion binding
				protein C-terminus binding
				specific transcriptional repressor activity
				transcription corepressor activity
				voltage-gated ion channel activity
Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438]	1.30802		biological process	transport
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				membrane fraction
			molecular function	ATP binding
				ATPase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.