MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 301 to 350 of 688 in total

Class  : cellular component

description	Ratio	Regulation	Gene Ontology
KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	1.66123	up	membrane
Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	3.89584		integral to membrane
			membrane
			membrane fraction
LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	1.50206		endoplasmic reticulum
			integral to membrane
			membrane
			nucleus
Lariat debranching enzyme (EC 3.1.-.-). [Uniprot/SWISSPROT;Acc:Q9UK59]	1.37411
leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]	2.79087	down	integral to membrane
			membrane
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	4.62042		integral to membrane
			integral to plasma membrane
			membrane
			plasma membrane
leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	1.76583		endoplasmic reticulum lumen
Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]	1.30207		AP-1 adaptor complex
			AP-2 adaptor complex
			basal plasma membrane
			cytoplasm
			cytosol
			early endosome
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	1.24361		endoplasmic reticulum
			ER-Golgi intermediate compartment
			Golgi apparatus
			integral to membrane
			membrane
			membrane fraction
MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	7.45006		integral to membrane
Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	1.29952		cytoplasm
			nucleus
Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	1.20102	up	endosome
			integral to membrane
			membrane
			plasma membrane
Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	1.22576		nucleus
Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	2.58329	down
Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	1.69856	up	cytoplasm
Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	1.24114	down	intracellular
			myosin complex
			striated muscle thick filament
Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	1.23668		myosin complex
			unconventional myosin complex
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	1.35022	up	cellular_component
			intracellular
			mitochondrion
			nucleoplasm
			nucleus
Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Uniprot/SWISSPROT;Acc:P55160]	1.47697		integral to plasma membrane
			membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.