MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 301 to 350 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	1.49271	cellular component	cellular_component
		molecular function	molecular_function
			protein binding
Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]	1.36349	biological process	regulation of progression through cell cycle
			spermatogenesis
Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	1.75846		amino acid metabolic process
			L-cystine transport
			transport
		cellular component	integral to membrane
			lysosomal membrane
			lysosome
			membrane
		molecular function	L-cystine transporter activity
Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	1.18821	biological process	cytokine and chemokine mediated signaling pathway
			respiratory gaseous exchange
			signal transduction
		cellular component	granulocyte macrophage colony-stimulating factor receptor complex
			integral to membrane
			membrane
		molecular function	hematopoietin/interferon-class (D200-domain) cytokine receptor activity
			interleukin receptor activity
			interleukin-3 receptor activity
			interleukin-5 receptor activity
			receptor activity
Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	1.44004	biological process	signal transduction
		cellular component	extracellular space
			soluble fraction
		molecular function	receptor binding
DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]	4.90535		protein binding
Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]	1.21384	biological process	metabolic process
		cellular component	nucleus
		molecular function	catalytic activity
			transcription factor binding
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	6.56408	biological process	transcription
			transcription from RNA polymerase III promoter
		cellular component	DNA-directed RNA polymerase III complex
			nucleoplasm
			nucleus
		molecular function	DNA-directed RNA polymerase activity
			protein binding
Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	1.41851	biological process	MAPKKK cascade
			nervous system development
			transmembrane receptor protein tyrosine kinase signaling pathway
		molecular function	insulin receptor binding
			transmembrane receptor protein tyrosine kinase signaling protein activity
E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	1.30869	biological process	cell cycle
			cell division
			mitosis
			mitotic cell cycle
			mitotic checkpoint

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.