MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	description	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 290 to 339 of 2667 in total

Ratio	description	Regulation	Class	Gene Ontology
1.19496	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	up	molecular function	isocitrate dehydrogenase (NADP+) activity
				magnesium ion binding
				manganese ion binding
				oxidoreductase activity
				oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
1.19539	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]		biological process	amino acid metabolic process
				metabolic process
				protein complex assembly
				sulfur amino acid metabolic process
			cellular component	cytoplasm
				cytosol
				mitochondrion
				nucleus
			molecular function	catalytic activity
				cysteine desulfurase activity
				lyase activity
				pyridoxal phosphate binding
				transaminase activity
				transferase activity
1.19545	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]		biological process	apoptosis
				DNA catabolic process
				DNA metabolic process
				erythrocyte differentiation
				multicellular organismal development
			cellular component	extracellular region
				lysosome
			molecular function	deoxyribonuclease II activity
				DNA binding
				endodeoxyribonuclease activity
				endonuclease activity
				hormone activity
				hydrolase activity
				protein binding
1.20102	Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]		biological process	apoptosis
				cell cycle
				electron transport
				ion transport
				iron ion transport
			cellular component	endosome
				integral to membrane
				membrane
				plasma membrane
			molecular function	copper ion binding
				FAD binding
				ferric-chelate reductase activity
				iron ion binding
				metal ion binding
				oxidoreductase activity
1.20481	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	down	biological process	biological_process
				generation of precursor metabolites and energy

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.