MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2601 to 2650 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
5.81102	up	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	cellular component	cytoskeleton
				nucleus
			molecular function	metal ion binding
				protein binding
				zinc ion binding
5.83544	down	Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	biological process	chromatin remodeling
				embryonic development
				oocyte differentiation
				positive regulation of meiosis
				regulation of exit from mitosis
				single fertilization
			cellular component	cytoplasmic chromatin
				nuclear chromatin
				nucleus
			molecular function	histone binding
				nucleic acid binding
5.84607		Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	biological process	axonogenesis
				beta-tubulin folding
				microtubule cytoskeleton organization and biogenesis
				protein folding
				protein modification process
			cellular component	cytoplasm
				cytoskeleton
				microtubule
			molecular function	chaperone binding
				protein binding
6.3909		Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	apoptosis
				intracellular signaling cascade
				negative regulation of cell growth
				regulation of transcription, DNA-dependent
				response to stress
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	metal ion binding
				protein binding
				zinc ion binding
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	biological process	protein amino acid phosphorylation
			molecular function	ATP binding
				magnesium ion binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	biological process	transcription
				transcription from RNA polymerase III promoter
			cellular component	DNA-directed RNA polymerase III complex
				nucleoplasm
				nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.