MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	description	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2569 to 2618 of 2667 in total

Class  : molecular function

Ratio	Regulation	description	Gene Ontology
4.14557	down	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	protein kinase activity
			protein serine/threonine kinase activity
			transferase activity
4.22898	up	Enoyl-CoA hydratase domain-containing protein 1. [Uniprot/SWISSPROT;Acc:Q9NTX5]	catalytic activity
4.40598		GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]
			GMP reductase activity
			metal ion binding
			oxidoreductase activity
			potassium ion binding
4.40797	down	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	aldehyde dehydrogenase (NAD) activity
			aldehyde dehydrogenase [NAD(P)+] activity
			electron carrier activity
			neuropeptide hormone activity
			oxidoreductase activity
4.4149		X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	DNA binding
			protein dimerization activity
			sequence-specific DNA binding
			transcription factor activity
4.49282		Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	transcriptional activator activity
			transcriptional repressor activity
4.49844		Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	hormone activity
4.55177	up	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	DNA binding
			transcription factor activity
4.55371		Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	G-protein coupled receptor activity
			parathyroid hormone receptor activity
			receptor activity
4.67988		Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	delayed rectifier potassium channel activity
			ion channel activity
			outward rectifier potassium channel activity
			potassium ion binding
			protein binding
			sodium:dicarboxylate symporter activity
			voltage-gated ion channel activity
			voltage-gated potassium channel activity
4.69231	down	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	acetyltransferase activity
			arylamine N-acetyltransferase activity
			transferase activity
4.71132		Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	magnesium ion binding
			potassium ion binding
			pyruvate kinase activity
			transferase activity
4.87049	up	zinc finger, FYVE domain containing 26 [RefSeq_peptide;Acc:NP_056161]	metal ion binding
			nucleic acid binding
			zinc ion binding
4.90535	down	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]	protein binding
5.01332	up	Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]	cysteine-type peptidase activity
			thiolester hydrolase activity
5.19755		Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	hormone binding
			identical protein binding
			protein heterodimerization activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.