MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2551 to 2600 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
5.19755	up	Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	molecular function	receptor activity
5.23046	down	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	biological process	G-protein coupled receptor protein signaling pathway
				negative regulation of apoptosis
				phosphoinositide phosphorylation
				phosphoinositide-mediated signaling
				protein amino acid phosphorylation
			cellular component	phosphoinositide 3-kinase complex
			molecular function	1-phosphatidylinositol-3-kinase activity
				inositol or phosphatidylinositol kinase activity
				phosphatidylinositol-4,5-bisphosphate 3-kinase activity
				phosphotransferase activity, alcohol group as acceptor
				protein binding
				transferase activity
5.31521	up	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	biological process	protein transport
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				nucleotide binding
				protein binding
5.32612	down	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	biological process	cellular respiration
				heart development
				inflammatory response
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	cytoplasm
				nucleus
			molecular function	protein binding
				transcription coactivator activity
				transcription factor activity
5.53059	up	rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	biological process	intracellular protein transport
				nucleocytoplasmic transport
				protein transport
				signal transduction
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				GTPase activity
				heat shock protein binding
				nucleotide binding
				protein binding
5.61927	down	RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	biological process	transport
			cellular component	integral to membrane
				membrane
			molecular function	metal ion binding
				nucleoside transporter activity
				protein binding
				zinc ion binding
5.81102	up	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	cellular component	cell surface
				cytoplasm

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.