MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2519 to 2568 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	8.21788	up	molecular function	translation regulator activity
Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	1.59763	down	biological process	protein modification process
				ubiquitin cycle
			cellular component	cytoplasm
			molecular function	ATP binding
				ligase activity
				nucleotide binding
				small conjugating protein ligase activity
				ubiquitin-protein ligase activity
Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	1.49444	up	biological process	protein modification process
				ubiquitin cycle
			molecular function	ligase activity
				small conjugating protein ligase activity
				ubiquitin-protein ligase activity
Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]	5.01332		biological process	ubiquitin cycle
			molecular function	cysteine-type peptidase activity
				thiolester hydrolase activity
Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	1.27516		cellular component	microtubule cytoskeleton
Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	4.21401	down		membrane
Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	1.80942			integral to membrane
				membrane
Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]	2.85383			integral to membrane
				membrane
Uncharacterized protein C2orf29. [Uniprot/SWISSPROT;Acc:Q9UKZ1]	4.1026	up	biological process	cell proliferation
			cellular component	cellular_component
			molecular function	molecular_function
Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]	1.65422		biological process	signal transduction
			cellular component	intracellular
Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]	3.41415		biological process	calcium ion transport
				ion transport
			cellular component	integral to membrane
				membrane
				voltage-gated calcium channel complex
			molecular function	calcium ion binding
				voltage-gated calcium channel activity
				voltage-gated ion channel activity
WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]	1.54676	down	biological process	cell adhesion
			cellular component	actin cytoskeleton
				extracellular region
			molecular function	actin binding
				hormone activity
				structural molecule activity
Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]	1.48363		biological process	cell cycle
				cell division
				mitosis
				protein amino acid phosphorylation
				regulation of progression through cell cycle
			cellular component	nucleus
			molecular function	ATP binding
				magnesium ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.