MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2501 to 2550 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	2.10428	molecular function	sequence-specific DNA binding
			transcription factor activity
Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]	3.81736	biological process	cell cycle
			homoiothermy
			regulation of progression through cell cycle
			regulation of transcription, DNA-dependent
			response to freezing
			transcription
			transcription initiation from RNA polymerase II promoter
		cellular component	nucleus
			transcription factor complex
		molecular function	ice binding
			protein binding
			transcription factor activity
Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	1.45624	biological process	circulation
			hemostasis
			multicellular organismal development
			regulation of transcription
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	DNA binding
			protein dimerization activity
			sequence-specific DNA binding
			transcription coactivator activity
			transcription factor activity
Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	4.55177	biological process	establishment and/or maintenance of chromatin architecture
			nervous system development
			regulation of transcription, DNA-dependent
			transcription
		cellular component	chromatin
			nucleus
		molecular function	DNA binding
			transcription factor activity
Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	1.59177	biological process	actomyosin structure organization and biogenesis
			muscle development
		molecular function	actin binding
			protein binding
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	1.60668	biological process	calcium ion homeostasis
			calcium ion transport
			ion transport
			osmosensory signaling pathway
			regulation of cell volume
			response to mechanical stimulus
		cellular component	integral to membrane
			membrane
			plasma membrane
		molecular function	calcium channel activity
			calcium ion binding
			calmodulin binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.