MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene	Gene Ontology	Regulation	Class	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 251 to 300 of 2667 in total

description	Ratio	Gene Ontology	Regulation	Class
Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	1.49558	embryonic development	down	biological process
		epithelial to mesenchymal transition
		extracellular region		cellular component
		extracellular space
		growth		biological process
		growth factor activity		molecular function
		inflammatory response		biological process
		negative regulation of cell proliferation
		negative regulation of progression through cell cycle
		odontogenesis (sensu Vertebrata)
		organ morphogenesis
		osteoblast differentiation
		positive regulation of astrocyte differentiation
		positive regulation of ossification
		positive regulation of osteoblast differentiation
		protein binding		molecular function
		regulation of transcription		biological process
		transforming growth factor beta receptor binding		molecular function
		ureteric bud branching		biological process
BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	1.73291	membrane	up	cellular component
		potassium ion transport		biological process
		protein binding		molecular function
		voltage-gated potassium channel activity
		voltage-gated potassium channel complex		cellular component
Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	1.24359	calcium ion binding	down	molecular function
		cell junction		cellular component
		cytoplasmic vesicle
		exocytosis		biological process
		lipid binding		molecular function
		membrane		cellular component
		protein transport		biological process
		synapse		cellular component
Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	1.61673	ATP binding	up	molecular function
		calcium ion binding
		calmodulin binding
		cytoplasm		cellular component
		nucleotide binding		molecular function
		nucleus		cellular component
		protein amino acid phosphorylation		biological process
		protein kinase activity		molecular function
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		transferase activity
Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	1.29424	calcium ion binding	down
		ciliary or flagellar motility		biological process
		flagellin-based flagellum		cellular component
Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	1.61347	calcium ion binding		molecular function
		ciliary or flagellar motility		biological process
		epidermis development
		flagellin-based flagellum		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.