MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2469 to 2518 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
4.49282	down	Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	biological process	transcription
			cellular component	nuclear membrane
				nucleoplasm
				nucleus
			molecular function	transcriptional activator activity
				transcriptional repressor activity
4.49844		Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	cellular component	extracellular space
			molecular function	hormone activity
4.50619		Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	biological process	apoptosis
				phagocytosis
			cellular component	cytoplasm
				cytoskeleton
				membrane
4.55177	up	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	biological process	establishment and/or maintenance of chromatin architecture
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	chromatin
				nucleus
			molecular function	DNA binding
				transcription factor activity
4.55371		Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	biological process	G-protein signaling, coupled to cyclic nucleotide second messenger
				signal transduction
				skeletal development
			cellular component	cytoplasm
				integral to membrane
				integral to plasma membrane
				membrane
				nucleus
			molecular function	G-protein coupled receptor activity
				parathyroid hormone receptor activity
				receptor activity
4.62042	down	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	biological process	protein amino acid N-linked glycosylation
				visual perception
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				plasma membrane
4.67988	up	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	biological process	dicarboxylic acid transport
				ion transport
				potassium ion transport
			cellular component	integral to membrane
				membrane
				membrane fraction
				voltage-gated potassium channel complex
			molecular function	delayed rectifier potassium channel activity
				ion channel activity
				outward rectifier potassium channel activity
				potassium ion binding
				protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.