MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2451 to 2500 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
4.40797	down	molecular function	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	electron carrier activity
				neuropeptide hormone activity
				oxidoreductase activity
4.4149		biological process	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	immune response
				regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
		cellular component		nucleus
		molecular function		DNA binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
4.49282		biological process	Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	chromatin modification
				negative regulation of gene expression, epigenetic
				negative regulation of transcription from RNA polymerase II promoter
				positive regulation of transcription from RNA polymerase II promoter
				regulation of cell growth
				regulation of transcription, DNA-dependent
				transcription
		cellular component		nuclear membrane
				nucleoplasm
				nucleus
		molecular function		transcriptional activator activity
				transcriptional repressor activity
4.49844		cellular component	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	extracellular space
		molecular function		hormone activity
4.50619		biological process	Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	apoptosis
				phagocytosis
		cellular component		cytoplasm
				cytoskeleton
				membrane
4.55177	up	biological process	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	establishment and/or maintenance of chromatin architecture
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
		cellular component		chromatin
				nucleus
		molecular function		DNA binding
				transcription factor activity
4.55371		biological process	Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	G-protein signaling, coupled to cyclic nucleotide second messenger
				signal transduction
				skeletal development
		cellular component		cytoplasm
				integral to membrane
				integral to plasma membrane
				membrane
				nucleus
		molecular function		G-protein coupled receptor activity
				parathyroid hormone receptor activity
				receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.