MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2451 to 2500 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	up	1.60668	membrane	cellular component
			osmosensory signaling pathway	biological process
			plasma membrane	cellular component
			regulation of cell volume	biological process
			response to mechanical stimulus
transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]		1.16158	calcium channel activity	molecular function
			calcium ion transport	biological process
			ion channel activity	molecular function
			ion transport	biological process
			membrane	cellular component
transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]		2.8521	calcium channel activity	molecular function
			integral to plasma membrane	cellular component
			ion channel activity	molecular function
			ion transport	biological process
			membrane	cellular component
			membrane fraction
Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]		1.14915	cell-cell signaling	biological process
			integral to membrane	cellular component
			membrane
			receptor binding	molecular function
			signal transduction	biological process
			transport
Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	down	1.82063	integral to membrane	cellular component
			membrane
Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	up	3.14866	integral to membrane
			membrane
Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	down	1.31489	intracellular
			metal ion binding	molecular function
			protein binding
			zinc ion binding
Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]		5.84607	axonogenesis	biological process
			beta-tubulin folding
			chaperone binding	molecular function
			cytoplasm	cellular component
			cytoskeleton
			microtubule
			microtubule cytoskeleton organization and biogenesis	biological process
			protein binding	molecular function
			protein folding	biological process
			protein modification process
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	up	1.62709	cytoplasmic vesicle	cellular component
			dephosphorylation	biological process
			hydrolase activity	molecular function
			phosphoric monoester hydrolase activity
			protein amino acid dephosphorylation	biological process
			protein tyrosine phosphatase activity	molecular function
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]		1.07618	G-protein coupled receptor protein signaling pathway	biological process
			integral to membrane	cellular component
			metal ion binding	molecular function
			nucleic acid binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.