MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2440 to 2489 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
4.40598	up	GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	molecular function	GMP reductase activity
				metal ion binding
				oxidoreductase activity
				potassium ion binding
4.40797	down	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	biological process	alcohol metabolic process
				carbohydrate metabolic process
				metabolic process
				neuropeptide signaling pathway
			cellular component	mitochondrion
			molecular function	aldehyde dehydrogenase (NAD) activity
				aldehyde dehydrogenase [NAD(P)+] activity
				electron carrier activity
				neuropeptide hormone activity
				oxidoreductase activity
4.4149		X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	biological process	immune response
				regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	DNA binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
4.49282		Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	biological process	chromatin modification
				negative regulation of gene expression, epigenetic
				negative regulation of transcription from RNA polymerase II promoter
				positive regulation of transcription from RNA polymerase II promoter
				regulation of cell growth
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nuclear membrane
				nucleoplasm
				nucleus
			molecular function	transcriptional activator activity
				transcriptional repressor activity
4.49844		Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	cellular component	extracellular space
			molecular function	hormone activity
4.50619		Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	biological process	apoptosis
				phagocytosis
			cellular component	cytoplasm
				cytoskeleton
				membrane
4.55177	up	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	biological process	establishment and/or maintenance of chromatin architecture
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	chromatin
				nucleus
			molecular function	DNA binding
				transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.