MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 243 to 292 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.18821	down	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	molecular function	receptor activity
1.19117	up	Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]	biological process	G-protein coupled receptor protein signaling pathway
				transport
			cellular component	cytoplasm
				nucleus
			molecular function	GTP binding
				guanyl nucleotide binding
				nucleotide binding
				protein binding
				signal transducer activity
1.19134	down	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	biological process	cell-cell signaling
				determination of left/right symmetry
				proteolysis
				zygotic determination of anterior/posterior axis, embryo
			cellular component	endoplasmic reticulum
				intracellular
				membrane
			molecular function	calcium ion binding
				nucleic acid binding
				peptidase activity
				subtilase activity
				zinc ion binding
1.19207	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]	biological process	mRNA export from nucleus
				multicellular organismal development
				transport
			cellular component	cytoplasm
				intracellular
				nuclear RNA export factor complex
				nucleus
			molecular function	nucleotide binding
				protein binding
				RNA binding
1.19212	down	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	biological process	hormone biosynthetic process
				signal transduction
				thyroid hormone generation
			cellular component	extracellular region
			molecular function	hormone activity
1.19496	up	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	biological process	carbohydrate metabolic process
				glutathione metabolic process
				glyoxylate cycle
				isocitrate metabolic process
				metabolic process
				response to oxidative stress
				tricarboxylic acid cycle
			cellular component	cytoplasm
				cytosol
				peroxisome
			molecular function	isocitrate dehydrogenase (NADP+) activity
				magnesium ion binding
				manganese ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.