MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]	3.81736	up	molecular function	transcription factor activity
Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	3.29064	down	biological process	liver development
				muscle development
				positive regulation of transcription
				positive regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	chromatin binding
				DNA binding
				metal ion binding
				protein binding
				RNA polymerase II transcription factor activity, enhancer binding
				sequence-specific DNA binding
				transcription factor activity
				transcriptional activator activity
				zinc ion binding
Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	1.45624	up	biological process	circulation
				hemostasis
				multicellular organismal development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	DNA binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription coactivator activity
				transcription factor activity
Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	4.55177		biological process	establishment and/or maintenance of chromatin architecture
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	chromatin
				nucleus
			molecular function	DNA binding
				transcription factor activity
Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	1.59177		biological process	actomyosin structure organization and biogenesis
				muscle development
			molecular function	actin binding
				protein binding
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	1.60668		biological process	calcium ion homeostasis
				calcium ion transport
				ion transport
				osmosensory signaling pathway
				regulation of cell volume
				response to mechanical stimulus
			cellular component	integral to membrane
				membrane
				plasma membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.