MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	2.86298	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleus
		molecular function	DNA binding
			ligand-dependent nuclear receptor activity
			transcription factor activity
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]	1.21705	biological process	cellular protein metabolic process
			protein amino acid phosphorylation
			protein folding
			regulation of progression through cell cycle
		cellular component	chaperonin-containing T-complex
			cytoplasm
			cytosol
		molecular function	ATP binding
			nucleotide binding
			protein binding
			protein kinase activity
			unfolded protein binding
T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]	1.25147	biological process	cell-cell signaling
			immune response
			positive regulation of cell proliferation
			positive regulation of interleukin-2 biosynthetic process
			positive regulation of interleukin-4 biosynthetic process
			positive regulation of lymphotoxin A biosynthetic process
			positive regulation of T-helper 2 cell differentiation
			positive regulation of transcription
			T cell activation
			T cell proliferation
		cellular component	external side of plasma membrane
			integral to membrane
			plasma membrane
		molecular function	coreceptor activity
			protein binding
			transcriptional activator activity
TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]	3.36725	biological process	negative regulation of antiviral response by host
			negative regulation of protein kinase activity
			positive regulation of viral genome replication
			positive regulation of viral protein levels in host cell
			regulation of transcription from RNA polymerase II promoter
			regulation of viral transcription
		cellular component	intracellular
			nucleus
		molecular function	double-stranded RNA binding
			protein binding
			protein heterodimerization activity
TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	1.66679	biological process	protein amino acid ADP-ribosylation
		cellular component	nucleus
		molecular function	metal ion binding
			NAD+ ADP-ribosyltransferase activity
			nucleic acid binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.