MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 2667 in total

Regulation  : up

description	Ratio	Gene Ontology	Class
T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	2.86298	DNA binding	molecular function
		ligand-dependent nuclear receptor activity
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		transcription
		transcription factor activity	molecular function
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]	1.21705	ATP binding
		cellular protein metabolic process	biological process
		chaperonin-containing T-complex	cellular component
		cytoplasm
		cytosol
		nucleotide binding	molecular function
		protein amino acid phosphorylation	biological process
		protein binding	molecular function
		protein folding	biological process
		protein kinase activity	molecular function
		regulation of progression through cell cycle	biological process
		unfolded protein binding	molecular function
T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]	1.25147	cell-cell signaling	biological process
		coreceptor activity	molecular function
		external side of plasma membrane	cellular component
		immune response	biological process
		integral to membrane	cellular component
		plasma membrane
		positive regulation of cell proliferation	biological process
		positive regulation of interleukin-2 biosynthetic process
		positive regulation of interleukin-4 biosynthetic process
		positive regulation of lymphotoxin A biosynthetic process
		positive regulation of T-helper 2 cell differentiation
		positive regulation of transcription
		protein binding	molecular function
		T cell activation	biological process
		T cell proliferation
		transcriptional activator activity	molecular function
TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]	3.36725	double-stranded RNA binding
		intracellular	cellular component
		negative regulation of antiviral response by host	biological process
		negative regulation of protein kinase activity
		nucleus	cellular component
		positive regulation of viral genome replication	biological process
		positive regulation of viral protein levels in host cell
		protein binding	molecular function
		protein heterodimerization activity
		regulation of transcription from RNA polymerase II promoter	biological process
		regulation of viral transcription
TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	1.66679	metal ion binding	molecular function
		NAD+ ADP-ribosyltransferase activity
		nucleic acid binding
		nucleus	cellular component
		protein amino acid ADP-ribosylation	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.