MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	description	Regulation	Class	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2390 to 2439 of 2667 in total

Ratio	description	Regulation	Class	Gene Ontology
4.04651	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]	up	cellular component	nuclear envelope
				nucleus
			molecular function	microtubule binding
				protein binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
4.05743	Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]		biological process	response to stimulus
				sensory perception of sound
				visual perception
			cellular component	integral to membrane
				membrane
4.07995	AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]		biological process	insulin receptor signaling pathway
				intracellular protein transport
				protein complex assembly
				transport
				vesicle-mediated transport
			cellular component	cytoplasmic vesicle
				Golgi apparatus
				membrane
				membrane coat
				membrane coat adaptor complex
				transport vesicle
			molecular function	protein binding
				protein transporter activity
				transporter activity
4.1026	Uncharacterized protein C2orf29. [Uniprot/SWISSPROT;Acc:Q9UKZ1]		biological process	cell proliferation
			cellular component	cellular_component
			molecular function	molecular_function
4.14054	Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]		biological process	embryonic skeletal morphogenesis
				positive regulation of cell proliferation
			cellular component	intracellular
				nucleus
			molecular function	metal ion binding
				nucleic acid binding
				zinc ion binding
4.14557	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	down	biological process	protein amino acid phosphorylation
			cellular component	nucleus
			molecular function	ATP binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				transferase activity
4.21401	Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]		cellular component	membrane
4.22898	Enoyl-CoA hydratase domain-containing protein 1. [Uniprot/SWISSPROT;Acc:Q9NTX5]	up	biological process	metabolic process
			molecular function	catalytic activity
4.40598	GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]		biological process	metabolic process
				nucleotide metabolic process
				response to cold
			molecular function	catalytic activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.