MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2390 to 2439 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]	3.81736	up	biological process	cell cycle
				homoiothermy
				regulation of progression through cell cycle
				regulation of transcription, DNA-dependent
				response to freezing
				transcription
				transcription initiation from RNA polymerase II promoter
			cellular component	nucleus
				transcription factor complex
			molecular function	ice binding
				protein binding
				transcription factor activity
Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	3.29064	down	biological process	liver development
				muscle development
				positive regulation of transcription
				positive regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	chromatin binding
				DNA binding
				metal ion binding
				protein binding
				RNA polymerase II transcription factor activity, enhancer binding
				sequence-specific DNA binding
				transcription factor activity
				transcriptional activator activity
				zinc ion binding
Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	1.45624	up	biological process	circulation
				hemostasis
				multicellular organismal development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	DNA binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription coactivator activity
				transcription factor activity
Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	4.55177		biological process	establishment and/or maintenance of chromatin architecture
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	chromatin
				nucleus
			molecular function	DNA binding
				transcription factor activity
Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	1.59177		biological process	actomyosin structure organization and biogenesis
				muscle development

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.