MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2351 to 2400 of 2667 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
2.91954	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	RNA splicing	biological process
2.95579	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]	cytoplasm	cellular component
		cytoskeleton
		dephosphorylation	biological process
		hydrolase activity	molecular function
		nucleus	cellular component
		phosphoric monoester hydrolase activity	molecular function
		protein amino acid dephosphorylation	biological process
		protein tyrosine phosphatase activity	molecular function
		protein tyrosine/serine/threonine phosphatase activity
2.96739	Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	nucleus	cellular component
		protein binding	molecular function
3.03423	Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]	binding
		kinetochore	cellular component
		mitosis	biological process
		regulation of progression through cell cycle
		ubiquitin cycle
		ubiquitin ligase complex	cellular component
3.14866	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	integral to membrane
		membrane
3.21473	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641]	eukaryotic translation elongation factor 1 complex
		intracellular
		protein binding	molecular function
		translation elongation factor activity
		translational elongation	biological process
3.21581	NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	ATP binding	molecular function
		ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
		cytoplasm	cellular component
		endonuclease activity	molecular function
		hydrolase activity
		nucleotide binding
		protein binding
3.26367	Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]	homoiothermy	biological process
		ice binding	molecular function
		response to freezing	biological process
		type I hypersensitivity
3.31364	Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]	2-acylglycerol O-acyltransferase activity	molecular function
		acyltransferase activity
		diacylglycerol O-acyltransferase activity
		endoplasmic reticulum	cellular component
		glycerol metabolic process	biological process
		integral to membrane	cellular component
		lipid biosynthetic process	biological process
		lipid metabolic process
		membrane	cellular component
		membrane fraction
		transferase activity	molecular function
		triacylglycerol biosynthetic process	biological process
3.32356	Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]	aspartic-type endopeptidase activity	molecular function
		proteolysis	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.