MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2351 to 2400 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]	up	3.54414	protein binding	molecular function
			signal transducer activity
			Toll binding
TP53-target gene 5 protein (TP53-inducible gene 5 protein). [Uniprot/SWISSPROT;Acc:Q9Y2B4]		1.55844	intracellular signaling cascade	biological process
			molecular_function	molecular function
			negative regulation of cell growth	biological process
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	down	2.93895	cytoplasm	cellular component
			I-kappaB kinase/NF-kappaB cascade	biological process
			metal ion binding	molecular function
			protein binding
			signal transduction	biological process
			zinc ion binding	molecular function
Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	up	1.16921	cell differentiation	biological process
			DNA binding	molecular function
			multicellular organismal development	biological process
			nervous system development
			nucleus	cellular component
			regulation of transcription	biological process
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
			transcription cofactor activity	molecular function
			transcription factor activity
			transcription factor complex	cellular component
			transcription regulator activity	molecular function
Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]		2.10428	cellular process	biological process
			DNA binding	molecular function
			leading edge cell differentiation	biological process
			negative regulation of protein amino acid autophosphorylation
			nuclear chromosome	cellular component
			nucleus
			positive regulation of transcription from RNA polymerase II promoter	biological process
			protein dimerization activity	molecular function
			regulation of progression through cell cycle	biological process
			regulation of transcription
			regulation of transcription, DNA-dependent
			RNA polymerase II transcription factor activity	molecular function
			sequence-specific DNA binding
			transcription factor activity
			transcription factor complex	cellular component
Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]		3.81736	cell cycle	biological process
			homoiothermy
			ice binding	molecular function
			nucleus	cellular component
			protein binding	molecular function
			regulation of progression through cell cycle	biological process
			regulation of transcription, DNA-dependent
			response to freezing
			transcription
			transcription factor activity	molecular function
			transcription factor complex	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.