MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2351 to 2400 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
3.83977	down	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	regulation of transcription	biological process
			transcription
			transcription factor activity	molecular function
3.89584	up	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	cell communication	biological process
			integral to membrane	cellular component
			membrane
			membrane fraction
			molecular_function	molecular function
			Wnt receptor signaling pathway	biological process
3.99682	down	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	ATP binding	molecular function
			cell adhesion	biological process
			GPI anchor binding	molecular function
			interleukin-1 receptor activity
			membrane	cellular component
			protein amino acid phosphorylation	biological process
			protein binding	molecular function
			vascular endothelial growth factor receptor activity
4.03725	up	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]	cytoplasm	cellular component
			dephosphorylation	biological process
			hydrolase activity	molecular function
			integral to plasma membrane	cellular component
			membrane
			phosphoric monoester hydrolase activity	molecular function
			protein amino acid dephosphorylation	biological process
			protein homodimerization activity	molecular function
			protein tyrosine phosphatase activity
			receptor activity
			soluble fraction	cellular component
			transmembrane receptor protein tyrosine phosphatase activity	molecular function
			transmembrane receptor protein tyrosine phosphatase signaling pathway	biological process
4.04651		Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]	condensed nuclear chromosome	cellular component
			endosome
			integral to membrane
			membrane
			microtubule binding	molecular function
			mitotic spindle organization and biogenesis	biological process
			nuclear chromosome, telomeric region	cellular component
			nuclear envelope
			nuclear membrane organization and biogenesis	biological process
			nuclear migration
			nucleus	cellular component
			protein binding	molecular function
			protein dimerization activity
			regulation of transcription, DNA-dependent	biological process
			sequence-specific DNA binding	molecular function
			transcription factor activity
4.05743		Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]	integral to membrane	cellular component
			membrane
			response to stimulus	biological process
			sensory perception of sound

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.