MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2340 to 2389 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	1.19212	down	cellular component	extracellular region
			molecular function	hormone activity
Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]	3.54414	up	biological process	cell-cell signaling
				immune response
				inflammatory response
				intracellular signaling cascade
				leukocyte activation
				phosphorylation
			cellular component	cytoplasm
				interleukin-1 receptor complex
				interleukin-18 receptor complex
			molecular function	protein binding
				signal transducer activity
				Toll binding
TP53-target gene 5 protein (TP53-inducible gene 5 protein). [Uniprot/SWISSPROT;Acc:Q9Y2B4]	1.55844		biological process	intracellular signaling cascade
				negative regulation of cell growth
			molecular function	molecular_function
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	2.93895	down	biological process	I-kappaB kinase/NF-kappaB cascade
				signal transduction
			cellular component	cytoplasm
			molecular function	metal ion binding
				protein binding
				zinc ion binding
Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	1.16921	up	biological process	cell differentiation
				multicellular organismal development
				nervous system development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	nucleus
				transcription factor complex
			molecular function	DNA binding
				transcription cofactor activity
				transcription factor activity
				transcription regulator activity
Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	2.10428		biological process	cellular process
				leading edge cell differentiation
				negative regulation of protein amino acid autophosphorylation
				positive regulation of transcription from RNA polymerase II promoter
				regulation of progression through cell cycle
				regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	nuclear chromosome
				nucleus
				transcription factor complex
			molecular function	DNA binding
				protein dimerization activity
				RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.