MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Regulation	Gene	Accession	Class	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2301 to 2350 of 2667 in total

description	Ratio	Gene Ontology	Regulation	Class
TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	1.66679	NAD+ ADP-ribosyltransferase activity	up	molecular function
		nucleic acid binding
		nucleus		cellular component
		protein amino acid ADP-ribosylation		biological process
		protein binding		molecular function
		transferase activity, transferring glycosyl groups
		zinc ion binding
Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	3.07625	cell motility	down	biological process
		cell proliferation
		integral to membrane		cellular component
		membrane
Tetratricopeptide repeat protein 18 (TPR repeat protein 18). [Uniprot/SWISSPROT;Acc:Q5T0N1]	1.58115	binding	up	molecular function
THO complex subunit 2 (Tho2). [Uniprot/SWISSPROT;Acc:Q8NI27]	1.28698	mRNA processing		biological process
		mRNA transport
		nucleus		cellular component
		RNA binding		molecular function
		RNA splicing		biological process
		transport
Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	2.25955	aminoacyl-tRNA ligase activity	down	molecular function
		ATP binding
		cytoplasm		cellular component
		ligase activity		molecular function
		mitochondrion		cellular component
		nucleotide binding		molecular function
		threonine-tRNA ligase activity
		threonyl-tRNA aminoacylation		biological process
		translation
		tRNA aminoacylation for protein translation
Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	3.05037	calcium ion binding		molecular function
		cell adhesion		biological process
		extracellular region		cellular component
		heparin binding		molecular function
		protein binding
		proteinaceous extracellular matrix		cellular component
		structural molecule activity		molecular function
		substrate-bound cell migration, cell extension		biological process
Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	1.19212	extracellular region		cellular component
		hormone activity		molecular function
		hormone biosynthetic process		biological process
		signal transduction
		thyroid hormone generation
Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]	3.54414	cell-cell signaling	up
		cytoplasm		cellular component
		immune response		biological process
		inflammatory response
		interleukin-1 receptor complex		cellular component
		interleukin-18 receptor complex
		intracellular signaling cascade		biological process
		leukocyte activation
		phosphorylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.