MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	Gene Ontology	Class	description	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2301 to 2350 of 2667 in total

Ratio	Regulation	Gene Ontology	Class	description
3.64872	up	protein transport	biological process	GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]
		signal transduction
		small GTPase mediated signal transduction
3.66058	down	extracellular matrix	cellular component	olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293]
		extracellular matrix binding	molecular function
		latrotoxin receptor activity
		membrane	cellular component
		protein homodimerization activity	molecular function
3.70292	up	anatomical structure development	biological process	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]
		embryonic skeletal morphogenesis
		homoiothermy
		ice binding	molecular function
		inner ear morphogenesis	biological process
		multicellular organismal development
		myoblast migration
		nucleus	cellular component
		positive regulation of transcription	biological process
		regulation of transcription, DNA-dependent
		response to freezing
		sequence-specific DNA binding	molecular function
		striated muscle development	biological process
		thymus development
		transcription factor activity	molecular function
3.71868	down	nucleus	cellular component	Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]
		protein binding	molecular function
		translation	biological process
3.74971	up	glutathione peroxidase activity	molecular function	Glutathione peroxidase 6 precursor (EC 1.11.1.9). [Uniprot/SWISSPROT;Acc:P59796]
		oxidoreductase activity
		response to oxidative stress	biological process
		selenium binding	molecular function
3.76904		integral to membrane	cellular component	Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]
		membrane
		receptor activity	molecular function
3.81736		cell cycle	biological process	Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
		homoiothermy
		ice binding	molecular function
		nucleus	cellular component
		protein binding	molecular function
		regulation of progression through cell cycle	biological process
		regulation of transcription, DNA-dependent
		response to freezing
		transcription
		transcription factor activity	molecular function
		transcription factor complex	cellular component
		transcription initiation from RNA polymerase II promoter	biological process
3.83977	down	cytoplasm	cellular component	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]
		DNA binding	molecular function
		multicellular organismal development	biological process
		nuclear matrix	cellular component
		nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.