MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2251 to 2300 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
3.48558	up	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]	protein-tyrosine kinase activity	molecular function
			receptor activity
			signal transduction	biological process
			transferase activity	molecular function
			transmembrane receptor protein tyrosine kinase signaling pathway	biological process
3.52215	down	Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]	G-protein coupled receptor protein signaling pathway
			integral to membrane	cellular component
			melanocortin receptor activity	molecular function
			membrane	cellular component
			olfactory receptor activity	molecular function
			receptor activity
			response to stimulus	biological process
			rhodopsin-like receptor activity	molecular function
			sensory perception of smell	biological process
			signal transduction
3.54414	up	Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]	cell-cell signaling
			cytoplasm	cellular component
			immune response	biological process
			inflammatory response
			interleukin-1 receptor complex	cellular component
			interleukin-18 receptor complex
			intracellular signaling cascade	biological process
			leukocyte activation
			phosphorylation
			protein binding	molecular function
			signal transducer activity
			Toll binding
3.54799	down	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	calcium channel regulator activity
			G-protein coupled receptor protein signaling pathway	biological process
			GTPase activity	molecular function
			protein binding
			signal transducer activity
			signal transduction	biological process
3.54928		Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	cytoplasm	cellular component
			glycerol metabolic process	biological process
			glycerophosphodiester phosphodiesterase activity	molecular function
			hydrolase activity
			integral to membrane	cellular component
			membrane
3.62109		Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	nucleus
3.64872	up	GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]	cellular_component
			GTP binding	molecular function
			GTPase activity
			intracellular	cellular component
			intracellular protein transport	biological process
			locomotory behavior
			membrane	cellular component
			nucleocytoplasmic transport	biological process
			nucleotide binding	molecular function
			protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.