MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2240 to 2289 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.48313	down	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	molecular function	transcription factor activity
3.48558	up	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]	biological process	axon guidance
				protein amino acid phosphorylation
				signal transduction
				transmembrane receptor protein tyrosine kinase signaling pathway
			cellular component	integral to plasma membrane
				membrane
			molecular function	ATP binding
				axon guidance receptor activity
				ephrin receptor activity
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				receptor activity
				transferase activity
3.52215	down	Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]	biological process	G-protein coupled receptor protein signaling pathway
				response to stimulus
				sensory perception of smell
				signal transduction
			cellular component	integral to membrane
				membrane
			molecular function	melanocortin receptor activity
				olfactory receptor activity
				receptor activity
				rhodopsin-like receptor activity
3.54414	up	Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]	biological process	cell-cell signaling
				immune response
				inflammatory response
				intracellular signaling cascade
				leukocyte activation
				phosphorylation
			cellular component	cytoplasm
				interleukin-1 receptor complex
				interleukin-18 receptor complex
			molecular function	protein binding
				signal transducer activity
				Toll binding
3.54799	down	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	biological process	G-protein coupled receptor protein signaling pathway
				signal transduction
			molecular function	calcium channel regulator activity
				GTPase activity
				protein binding
				signal transducer activity
3.54928		Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	biological process	glycerol metabolic process
			cellular component	cytoplasm
				integral to membrane
				membrane
			molecular function	glycerophosphodiester phosphodiesterase activity
				hydrolase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.