MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2201 to 2250 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]	4.03725	cellular component	membrane
			soluble fraction
		molecular function	hydrolase activity
			phosphoric monoester hydrolase activity
			protein homodimerization activity
			protein tyrosine phosphatase activity
			receptor activity
			transmembrane receptor protein tyrosine phosphatase activity
Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264]	1.36997	biological process	angiogenesis
			cell differentiation
			multicellular organismal development
			signal transduction
		cellular component	cell junction
			cytoplasm
			cytoskeleton
			intracellular
			membrane
		molecular function	GTPase activator activity
			protein binding
Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	5.31521	biological process	protein transport
			small GTPase mediated signal transduction
		cellular component	intracellular
		molecular function	GTP binding
			nucleotide binding
			protein binding
RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]	3.35536	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleolus
			nucleus
		molecular function	calmodulin binding
RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	2.86965	biological process	DNA topological change
		cellular component	chromosome
			nucleus
		molecular function	ATP binding
			DNA binding
			DNA topoisomerase (ATP-hydrolyzing) activity
			nucleic acid binding
			nucleotide binding
			RNA binding
RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	1.42264	biological process	homoiothermy
			mRNA processing
			response to freezing
			RNA splicing
			translation
			type I hypersensitivity
		cellular component	cytoplasm
			intracellular
			nucleus
			ribosome
		molecular function	ice binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.