MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2201 to 2250 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.36725	up	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]	biological process	negative regulation of antiviral response by host
				negative regulation of protein kinase activity
				positive regulation of viral genome replication
				positive regulation of viral protein levels in host cell
				regulation of transcription from RNA polymerase II promoter
				regulation of viral transcription
			cellular component	intracellular
				nucleus
			molecular function	double-stranded RNA binding
				protein binding
				protein heterodimerization activity
3.39764	down	Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	biological process	biological_process
				muscle development
			cellular component	integral to membrane
				junctional membrane complex
				membrane
				microsome
				sarcoplasmic reticulum
				Z disc
			molecular function	molecular_function
				structural constituent of muscle
3.41415	up	Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]	biological process	calcium ion transport
				ion transport
			cellular component	integral to membrane
				membrane
				voltage-gated calcium channel complex
			molecular function	calcium ion binding
				voltage-gated calcium channel activity
				voltage-gated ion channel activity
3.41794		LRRC44 protein. [Uniprot/SPTREMBL;Acc:Q6P5P7]		protein binding
3.43019	down	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]	biological process	biological_process
				mRNA processing
				RNA splicing
			cellular component	nucleus
				spliceosome
			molecular function	protein binding
3.48313		Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	biological process	regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	sequence-specific DNA binding
				transcription factor activity
3.48558	up	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]	biological process	axon guidance
				protein amino acid phosphorylation
				signal transduction
				transmembrane receptor protein tyrosine kinase signaling pathway
			cellular component	integral to plasma membrane
				membrane
			molecular function	ATP binding
				axon guidance receptor activity
				ephrin receptor activity
				nucleotide binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.