MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2151 to 2200 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
3.27919	down	cellular component	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	endoplasmic reticulum
				Golgi apparatus
				membrane
				nucleus
		molecular function		calcium ion binding
				calcium-dependent protein binding
				DNA binding
				ion channel activity
				potassium channel activity
				potassium ion binding
				protein C-terminus binding
				specific transcriptional repressor activity
				transcription corepressor activity
				voltage-gated ion channel activity
3.29064		biological process	Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	liver development
				muscle development
				positive regulation of transcription
				positive regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
				transcription
		cellular component		nucleus
		molecular function		chromatin binding
				DNA binding
				metal ion binding
				protein binding
				RNA polymerase II transcription factor activity, enhancer binding
				sequence-specific DNA binding
				transcription factor activity
				transcriptional activator activity
				zinc ion binding
3.31364	up	biological process	Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]	glycerol metabolic process
				lipid biosynthetic process
				lipid metabolic process
				triacylglycerol biosynthetic process
		cellular component		endoplasmic reticulum
				integral to membrane
				membrane
				membrane fraction
		molecular function		2-acylglycerol O-acyltransferase activity
				acyltransferase activity
				diacylglycerol O-acyltransferase activity
				transferase activity
3.32356		biological process	Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]	proteolysis
		molecular function		aspartic-type endopeptidase activity
				sugar binding
3.35536		biological process	RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]	regulation of transcription, DNA-dependent
				transcription
		cellular component		nucleolus
				nucleus
		molecular function		calmodulin binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.