MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2151 to 2200 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
2.20843	ATP binding	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]	molecular function
	cytoplasm		cellular component
	glucose transport		biological process
	intracellular signaling cascade
	membrane fraction		cellular component
	nucleotide binding		molecular function
	protein amino acid autophosphorylation		biological process
	protein amino acid phosphorylation
	protein binding		molecular function
	protein kinase activity
	protein modification process		biological process
	protein serine/threonine kinase activity		molecular function
	protein-tyrosine kinase activity
	transferase activity
2.2866	catalytic activity	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]
	hydrolase activity
	magnesium ion binding
	manganese ion binding
	membrane fraction		cellular component
	neuron projection
	positive regulation of I-kappaB kinase/NF-kappaB cascade		biological process
	protein amino acid dephosphorylation
	protein binding		molecular function
	protein C-terminus binding
	protein phosphatase type 2C activity
	protein serine/threonine phosphatase activity
	protein serine/threonine phosphatase complex		cellular component
	signal transducer activity		molecular function
	voltage-gated calcium channel complex		cellular component
2.29381	cell death	Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	biological process
	chromatin binding		molecular function
	cytoplasm		cellular component
	intracellular
	nuclear organization and biogenesis		biological process
	nucleus		cellular component
	protein binding		molecular function
	visual perception		biological process
	zinc ion binding		molecular function
2.2939	cytoplasm	Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	cellular component
	organelle organization and biogenesis		biological process
	pigmentation
2.31039	maintenance of protein localization in nucleus	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]
	nucleus		cellular component
	protein binding		molecular function
	regulation of transcription, DNA-dependent		biological process
	transcription
2.37788	structural molecule activity	Coiled-coil domain-containing protein 83. [Uniprot/SWISSPROT;Acc:Q8IWF9]	molecular function
	viral capsid		cellular component
2.43098	lipid transport	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]	biological process
	steroid metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.