MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]	1.96673	up	biological process	proteolysis
				signal peptide processing
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
				microsome
			molecular function	peptidase activity
				serine-type peptidase activity
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	1.40552	down	biological process	amino acid metabolic process
				amino acid transport
				dicarboxylic acid transport
				neurotransmitter transport
			cellular component	integral to plasma membrane
				membrane
			molecular function	amino acid transporter activity
				neurotransmitter:sodium symporter activity
				sodium:dicarboxylate symporter activity
				symporter activity
Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	1.11083		biological process	neurotransmitter transport
			cellular component	integral to plasma membrane
				membrane
				plasma membrane
			molecular function	neurotransmitter:sodium symporter activity
				symporter activity
				transporter activity
Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	1.42215		biological process	monoamine transport
				neurotransmitter transport
				neurotransmitter uptake
				serotonin transport
			cellular component	integral to plasma membrane
				membrane
			molecular function	monoamine transporter activity
				neurotransmitter:sodium symporter activity
				protein binding
				serotonin transporter activity
				serotonin:sodium symporter activity
				symporter activity
Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	1.20619		biological process	ATP hydrolysis coupled proton transport
				cation transport
				hydrogen ion homeostasis
				metabolic process
				monovalent inorganic cation transport
				potassium ion transport
				proton transport
				sodium ion transport
				sperm motility
				transport
			cellular component	integral to membrane
				membrane
				sodium:potassium-exchanging ATPase complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.