MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
3.05037	down	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	heparin binding	molecular function
			protein binding
			proteinaceous extracellular matrix	cellular component
			structural molecule activity	molecular function
			substrate-bound cell migration, cell extension	biological process
3.06659		ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	ATP binding	molecular function
			nucleotide binding
3.07625		Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	cell motility	biological process
			cell proliferation
			integral to membrane	cellular component
			membrane
3.11758		Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	cytokine activity	molecular function
			extracellular region	cellular component
			extracellular space
			growth	biological process
			growth factor activity	molecular function
3.14866	up	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	integral to membrane	cellular component
			membrane
3.15011	down	Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]	calcium ion binding	molecular function
			cytoplasm	cellular component
			microtubule
3.21473	up	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641]	eukaryotic translation elongation factor 1 complex
			intracellular
			protein binding	molecular function
			translation elongation factor activity
			translational elongation	biological process
3.21581		NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	ATP binding	molecular function
			ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
			cytoplasm	cellular component
			endonuclease activity	molecular function
			hydrolase activity
			nucleotide binding
			protein binding
3.26367		Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]	homoiothermy	biological process
			ice binding	molecular function
			response to freezing	biological process
			type I hypersensitivity
3.27919	down	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	apoptosis
			behavior
			calcium ion binding	molecular function
			calcium-dependent protein binding
			cytoplasm	cellular component
			cytosol
			DNA binding	molecular function
			endoplasmic reticulum	cellular component
			Golgi apparatus
			ion channel activity	molecular function
			ion transport	biological process
			membrane	cellular component
			negative regulation of transcription from RNA polymerase II promoter	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.