MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	1.61987	biological process	apoptosis
			blood coagulation
			caspase activation
			cell motility
			elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
			establishment of synaptic specificity at neuromuscular junction
			G-protein coupled receptor protein signaling pathway
			multicellular organismal development
			negative regulation of neuron apoptosis
			positive regulation of calcium ion transport
			positive regulation of cell proliferation
			positive regulation of I-kappaB kinase/NF-kappaB cascade
			positive regulation of smooth muscle contraction
			positive regulation of vasoconstriction
			protein kinase C activation
			regulation of progression through cell cycle
			regulation of sensory perception of pain
			release of sequestered calcium ion into cytosol
			response to wounding
			signal transduction
			STAT protein nuclear translocation
			tyrosine phosphorylation of STAT protein
		cellular component	Golgi apparatus
			integral to membrane
			integral to plasma membrane
			neuromuscular junction
			plasma membrane
			postsynaptic membrane
		molecular function	G-protein coupled receptor activity
			purinergic nucleotide receptor activity, G-protein coupled
			receptor activity
			receptor binding
			rhodopsin-like receptor activity
			thrombin receptor activity
Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]	2.20843	biological process	glucose transport
			intracellular signaling cascade
			protein amino acid autophosphorylation
			protein amino acid phosphorylation
			protein modification process
		cellular component	cytoplasm
			membrane fraction
		molecular function	ATP binding
			nucleotide binding
			protein binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	5.53059	biological process	intracellular protein transport
			nucleocytoplasmic transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.