MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
3.05037	down	cellular component	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	proteinaceous extracellular matrix
		molecular function		calcium ion binding
				heparin binding
				protein binding
				structural molecule activity
3.06659			ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	ATP binding
				nucleotide binding
3.07625		biological process	Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	cell motility
				cell proliferation
		cellular component		integral to membrane
				membrane
3.11758		biological process	Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	growth
		cellular component		extracellular region
				extracellular space
		molecular function		cytokine activity
				growth factor activity
3.14866	up	cellular component	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	integral to membrane
				membrane
3.15011	down		Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]	cytoplasm
				microtubule
		molecular function		calcium ion binding
3.21473	up	biological process	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641]	translational elongation
		cellular component		eukaryotic translation elongation factor 1 complex
				intracellular
		molecular function		protein binding
				translation elongation factor activity
3.21581		cellular component	NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	cytoplasm
		molecular function		ATP binding
				ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
				endonuclease activity
				hydrolase activity
				nucleotide binding
				protein binding
3.26367		biological process	Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]	homoiothermy
				response to freezing
				type I hypersensitivity
		molecular function		ice binding
3.27919	down	biological process	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	apoptosis
				behavior
				ion transport
				negative regulation of transcription from RNA polymerase II promoter
				potassium ion transport
				regulation of neuron apoptosis
				regulation of transcription from RNA polymerase II promoter
				response to pain
				sensory perception of pain
				signal transduction
				transcription
		cellular component		cytoplasm
				cytosol

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.