MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	Class	description	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 2667 in total

Ratio	Regulation	Gene Ontology	Class	description
3.05037	down	heparin binding	molecular function	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]
		protein binding
		proteinaceous extracellular matrix	cellular component
		structural molecule activity	molecular function
		substrate-bound cell migration, cell extension	biological process
3.06659		ATP binding	molecular function	ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]
		nucleotide binding
3.07625		cell motility	biological process	Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]
		cell proliferation
		integral to membrane	cellular component
		membrane
3.11758		cytokine activity	molecular function	Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]
		extracellular region	cellular component
		extracellular space
		growth	biological process
		growth factor activity	molecular function
3.14866	up	integral to membrane	cellular component	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]
		membrane
3.15011	down	calcium ion binding	molecular function	Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]
		cytoplasm	cellular component
		microtubule
3.21473	up	eukaryotic translation elongation factor 1 complex		Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641]
		intracellular
		protein binding	molecular function
		translation elongation factor activity
		translational elongation	biological process
3.21581		ATP binding	molecular function	NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]
		ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
		cytoplasm	cellular component
		endonuclease activity	molecular function
		hydrolase activity
		nucleotide binding
		protein binding
3.26367		homoiothermy	biological process	Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]
		ice binding	molecular function
		response to freezing	biological process
		type I hypersensitivity
3.27919	down	apoptosis		Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
		behavior
		calcium ion binding	molecular function
		calcium-dependent protein binding
		cytoplasm	cellular component
		cytosol
		DNA binding	molecular function
		endoplasmic reticulum	cellular component
		Golgi apparatus
		ion channel activity	molecular function
		ion transport	biological process
		membrane	cellular component
		negative regulation of transcription from RNA polymerase II promoter	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.