MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.95876	Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]	molecular function	protein binding
1.96673	Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]	biological process	proteolysis
			signal peptide processing
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
			microsome
		molecular function	peptidase activity
			serine-type peptidase activity
1.98149	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]	biological process	anti-apoptosis
			B cell differentiation
			B cell proliferation
			immune response
			inflammatory response
			isotype switching
			leukocyte adhesion
			platelet activation
			regulation of immunoglobulin secretion
		cellular component	extracellular space
			integral to membrane
			integral to plasma membrane
			membrane
			soluble fraction
		molecular function	CD40 receptor binding
			cytokine activity
			tumor necrosis factor receptor binding
2.07532	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	biological process	cytoskeletal anchoring
		cellular component	cell junction
			cytoplasm
			dendrite
			intracellular
			membrane fraction
			postsynaptic membrane
			synapse
		molecular function	protein binding
2.10428	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	biological process	cellular process
			leading edge cell differentiation
			negative regulation of protein amino acid autophosphorylation
			positive regulation of transcription from RNA polymerase II promoter
			regulation of progression through cell cycle
			regulation of transcription
			regulation of transcription, DNA-dependent
		cellular component	nuclear chromosome
			nucleus
			transcription factor complex
		molecular function	DNA binding
			protein dimerization activity
			RNA polymerase II transcription factor activity
			sequence-specific DNA binding
			transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.