MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2093 to 2142 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.03423	up	Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]	biological process	regulation of progression through cell cycle
				ubiquitin cycle
			cellular component	kinetochore
				ubiquitin ligase complex
			molecular function	binding
3.05037	down	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	biological process	cell adhesion
				substrate-bound cell migration, cell extension
			cellular component	extracellular region
				proteinaceous extracellular matrix
			molecular function	calcium ion binding
				heparin binding
				protein binding
				structural molecule activity
3.06659		ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]		ATP binding
				nucleotide binding
3.07625		Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	biological process	cell motility
				cell proliferation
			cellular component	integral to membrane
				membrane
3.11758		Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	biological process	growth
			cellular component	extracellular region
				extracellular space
			molecular function	cytokine activity
				growth factor activity
3.14866	up	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	cellular component	integral to membrane
				membrane
3.15011	down	Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]		cytoplasm
				microtubule
			molecular function	calcium ion binding
3.21473	up	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641]	biological process	translational elongation
			cellular component	eukaryotic translation elongation factor 1 complex
				intracellular
			molecular function	protein binding
				translation elongation factor activity
3.21581		NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	cellular component	cytoplasm
			molecular function	ATP binding
				ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
				endonuclease activity
				hydrolase activity
				nucleotide binding
				protein binding
3.26367		Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]	biological process	homoiothermy
				response to freezing
				type I hypersensitivity
			molecular function	ice binding
3.27919	down	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	biological process	apoptosis
				behavior
				ion transport
				negative regulation of transcription from RNA polymerase II promoter
				potassium ion transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.