MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Gene Ontology	Ratio	Class	Gene	Regulation	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 2667 in total

description	Gene Ontology	Ratio	Class	Regulation
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	protein binding	1.22178	molecular function	up
	protein kinase activity
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
	transition metal ion binding
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	ATP binding	4.14557		down
	nucleotide binding
	nucleus		cellular component
	protein amino acid phosphorylation		biological process
	protein kinase activity		molecular function
	protein serine/threonine kinase activity
	transferase activity
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	cytoplasm	2.31699	cellular component
	hydrolase activity		molecular function
	iron ion binding
	manganese ion binding
	metal ion binding
	phosphoprotein phosphatase activity
	protein amino acid dephosphorylation		biological process
	protein binding		molecular function
	protein phosphatase type 2A activity
	protein phosphatase type 2A complex		cellular component
Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	calcium ion binding	1.59819	molecular function	up
	detection of stimulus during sensory perception		biological process
	hydrolase activity		molecular function
	iron ion binding
	manganese ion binding
	phosphoprotein phosphatase activity
	protein amino acid dephosphorylation		biological process
	protein serine/threonine phosphatase activity		molecular function
	response to stimulus		biological process
	visual perception
SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	negative regulation of cell growth	2.83611		down
	nucleus		cellular component
	positive regulation of transcription		biological process
	protein binding		molecular function
	regulation of transcription, DNA-dependent		biological process
	transcription
	transcriptional activator activity		molecular function
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	cell junction	2.07532	cellular component	up
	cytoplasm
	cytoskeletal anchoring		biological process
	dendrite		cellular component
	intracellular
	membrane fraction
	postsynaptic membrane
	protein binding		molecular function
	synapse		cellular component
Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]	lipid binding	7.27043	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.