MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	1.22178	up	molecular function	protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
				transition metal ion binding
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	4.14557	down	biological process	protein amino acid phosphorylation
			cellular component	nucleus
			molecular function	ATP binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				transferase activity
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	2.31699		biological process	protein amino acid dephosphorylation
			cellular component	cytoplasm
				protein phosphatase type 2A complex
			molecular function	hydrolase activity
				iron ion binding
				manganese ion binding
				metal ion binding
				phosphoprotein phosphatase activity
				protein binding
				protein phosphatase type 2A activity
Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	1.59819	up	biological process	detection of stimulus during sensory perception
				protein amino acid dephosphorylation
				response to stimulus
				visual perception
			molecular function	calcium ion binding
				hydrolase activity
				iron ion binding
				manganese ion binding
				phosphoprotein phosphatase activity
				protein serine/threonine phosphatase activity
SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	2.83611	down	biological process	negative regulation of cell growth
				positive regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	protein binding
				transcriptional activator activity
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	2.07532	up	biological process	cytoskeletal anchoring
			cellular component	cell junction
				cytoplasm
				dendrite
				intracellular
				membrane fraction
				postsynaptic membrane
				synapse
			molecular function	protein binding
Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]	7.27043			lipid binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.